Jul 16, 2014 · Background. Children with Idiopathic Short Stature do not attain a normal adult height. The improvement of adult height with treatment with recombinant human growth hormone (rhGH), at doses of 0.16 to 0.28 mg/kg/week is modest, usually less that 4 cm, and they remain short as adults.Cited by: 12. Short stature refers to a height of a human being which is below typical. Whether a person is considered short depends on the context. Because of the lack of preciseness, there is often disagreement about the degree of shortness that should be called short.. In a medical context, short stature is typically defined as an adult height that is more than two standard deviations below the mean for Specialty: Endocrinology.
Deodati A, Cianfarani S. Impact of growth hormone therapy on adult height of children with idiopathic short stature: systematic review. BMJ 2011; 342:c7157. Albertsson-Wikland K, Aronson AS, Gustafsson J, et al. Dose-dependent effect of growth hormone on final height in children with short stature without growth hormone deficiency. Short-term administration of growth hormone to children with idiopathic short stature results in increases in growth rate and standard-deviation scores for height. However, the effect of long-term Cited by: 299.
See "In children with idiopathic short stature, what advantage does administering recombinant growth hormone have over observation in final adult height?" on page 571. The research literature suggests that recombinant growth hormone, when compared with no therapeutic agents, increases the final adult height in short normal children.Author: Titus Chan, Terry P Klassen. Jul 18, 2007 · There is some evidence that recombinant human growth hormone improves short term growth and (near) final adult height in children with idiopathic short stature.. Idiopathic short stature is the term used when children are very short compared with others of .